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Sun Feb 10, 2013, 10:38 PM

Genetically engineered virus kills cancer

Source: Bangkok Post

Genetically engineered virus kills cancer: study
Published: 11 Feb 2013 at 01.44Online news: World
A genetically-engineered virus tested in 30 terminally-ill liver cancer patients significantly prolonged their lives, killing tumours and inhibiting the growth of new ones, scientists reported on Sunday.


A patient undergoes a scanner as radiology technicians look at the exam on a screen, on February 6, 2013, at a medical unit specialised in cancer treatment in France. A genetically-engineered virus tested in 30 terminally-ill liver cancer patients significantly prolonged their lives, killing tumours and inhibiting the growth of new ones, scientists reported on Sunday.

Sixteen patients given a high dose of the therapy survived for 14.1 months on average, compared to 6.7 months for the 14 who got the low dose.

"For the first time in medical history we have shown that a genetically-engineered virus can improve survival of cancer patients," study co-author David Kirn told AFP.

The four-week trial with the vaccine Pexa-Vec or JX-594, reported in the journal Nature Medicine, may hold promise for the treatment of advanced solid tumours.

Read more: http://www.bangkokpost.com/news/world/335320/genetically-engineered-virus-kills-cancer-study

25 replies, 3441 views

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Arrow 25 replies Author Time Post
Reply Genetically engineered virus kills cancer (Original post)
kpete Feb 2013 OP
JohnnyLib2 Feb 2013 #1
defacto7 Feb 2013 #2
loudsue Feb 2013 #3
SkyDaddy7 Feb 2013 #7
mopinko Feb 2013 #12
farminator3000 Feb 2013 #15
valerief Feb 2013 #8
farminator3000 Feb 2013 #16
valerief Feb 2013 #24
Ken Burch Feb 2013 #4
glinda Feb 2013 #5
valerief Feb 2013 #9
farminator3000 Feb 2013 #17
cartach Feb 2013 #6
Dalai_1 Feb 2013 #10
farminator3000 Feb 2013 #11
mopinko Feb 2013 #13
farminator3000 Feb 2013 #14
mopinko Feb 2013 #21
farminator3000 Feb 2013 #22
farminator3000 Feb 2013 #18
farminator3000 Feb 2013 #19
sofa king Feb 2013 #20
farminator3000 Feb 2013 #23
kelliekat44 Feb 2013 #25

Response to kpete (Original post)

Sun Feb 10, 2013, 10:49 PM

1. Hope, hope, hope this holds up and is the foundation for more. n/t

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Response to kpete (Original post)

Mon Feb 11, 2013, 12:18 AM

2. I do too....

Beware though. I have seen amazing cures disappear soon after they are reported. There was an article in a science journal of a cure for liver cancer that had almost 90% cure rate in the first trials on the most terminally ill patients. It disappeared from view within weeks of the report and I never heard about it again. That was almost 2 years ago.

Here is another that has just dissipated into the mists on a different cure for viral infections. It's the only one I kept on file for the record if it also disappeared...

http://medicalxpress.com/news/2011-08-drug-viral-infection.html

Most bacterial infections can be treated with antibiotics such as penicillin, discovered decades ago. However, such drugs are useless against viral infections, including influenza, the common cold, and deadly hemorrhagic fevers such as Ebola.

Now, in a development that could transform how viral infections are treated, a team of researchers at MIT’s Lincoln Laboratory has designed a drug that can identify cells that have been infected by any type of virus, then kill those cells to terminate the infection.

In a paper published July 27 in the journal PLoS One, the researchers tested their drug against 15 viruses, and found it was effective against all of them — including rhinoviruses that cause the common cold, H1N1 influenza, a stomach virus, a polio virus, dengue fever and several other types of hemorrhagic fever.

The drug works by targeting a type of RNA produced only in cells that have been infected by viruses. “In theory, it should work against all viruses,” says Todd Rider, a senior staff scientist in Lincoln Laboratory’s Chemical, Biological, and Nanoscale Technologies Group who invented the new technology.

Because the technology is so broad-spectrum, it could potentially also be used to combat outbreaks of new viruses, such as the 2003 SARS (severe acute respiratory syndrome) outbreak, Rider says.

Other members of the research team are Lincoln Lab staff members Scott Wick, Christina Zook, Tara Boettcher, Jennifer Pancoast and Benjamin Zusman.

Few antivirals available

Rider had the idea to try developing a broad-spectrum antiviral therapy about 11 years ago, after inventing CANARY (Cellular Analysis and Notification of Antigen Risks and Yields), a biosensor that can rapidly identify pathogens. “If you detect a pathogenic bacterium in the environment, there is probably an antibiotic that could be used to treat someone exposed to that, but I realized there are very few treatments out there for viruses,” he says.

There are a handful of drugs that combat specific viruses, such as the protease inhibitors used to control HIV infection, but these are relatively few in number and susceptible to viral resistance.

Rider drew inspiration for his therapeutic agents, dubbed DRACOs (Double-stranded RNA Activated Caspase Oligomerizers), from living cells’ own defense systems.

When viruses infect a cell, they take over its cellular machinery for their own purpose — that is, creating more copies of the virus. During this process, the viruses create long strings of double-stranded RNA (dsRNA), which is not found in human or other animal cells.

As part of their natural defenses against viral infection, human cells have proteins that latch onto dsRNA, setting off a cascade of reactions that prevents the virus from replicating itself. However, many viruses can outsmart that system by blocking one of the steps further down the cascade.

Rider had the idea to combine a dsRNA-binding protein with another protein that induces cells to undergo apoptosis (programmed cell suicide) — launched, for example, when a cell determines it is en route to becoming cancerous. Therefore, when one end of the DRACO binds to dsRNA, it signals the other end of the DRACO to initiate cell suicide.

Combining those two elements is a “great idea” and a very novel approach, says Karla Kirkegaard, professor of microbiology and immunology at Stanford University. “Viruses are pretty good at developing resistance to things we try against them, but in this case, it’s hard to think of a simple pathway to drug resistance,” she says.

Each DRACO also includes a “delivery tag,” taken from naturally occurring proteins, that allows it to cross cell membranes and enter any human or animal cell. However, if no dsRNA is present, DRACO leaves the cell unharmed.

Most of the tests reported in this study were done in human and animal cells cultured in the lab, but the researchers also tested DRACO in mice infected with the H1N1 influenza virus. When mice were treated with DRACO, they were completely cured of the infection. The tests also showed that DRACO itself is not toxic to mice.

The researchers are now testing DRACO against more viruses in mice and beginning to get promising results. Rider says he hopes to license the technology for trials in larger animals and for eventual human clinical trials.

More information: Rider TH, et al. (2011) Broad-Spectrum Antiviral Therapeutics. PLoS ONE 6(7): e22572. doi:10.1371/journal.pone.0022572

Provided by Massachusetts Institute of Technology (news : web)


Let's hope the one you have posted survives. In the mean time, keep a record for your own reference just in case.

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Response to defacto7 (Reply #2)

Mon Feb 11, 2013, 01:01 AM

3. The fact that GMO corn & soy beans mess with people's RNA might have triggered some

negative responses in test subjects who had consumed a good quantity of the GMO toxins (for lack of a better word). I just read an article on DU a couple of days ago about the GMO's making a mess of RNA.

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Response to loudsue (Reply #3)

Mon Feb 11, 2013, 07:35 AM

7. I have never read any...

peer reviewed study that says GMOs are unhealthy...I would love to read what you did so i can track it back to its source...Tracking articles back to their source tends to get one the real truth. I hate to say it but I have seen some articles written against GMF that take on a very similar MO as do climate change deniers.

I am not defending GMF...But what i am saying is, like vaccines, there is not any science backing many of the claims folks make. I will change my mind the instant there is science to warrant a change of mind...Not emotion.

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Response to SkyDaddy7 (Reply #7)

Mon Feb 11, 2013, 10:06 AM

12. +1

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Response to SkyDaddy7 (Reply #7)

Mon Feb 11, 2013, 10:25 AM

15. have you read any...

saying they ARE healthy? and by whom?

http://truth-out.org/news/item/12284-inside-the-controversy-over-a-french-gmo-study-and-the-monsanto-information-war

"When an industry study comes out poorly designed, they don't trash it," said Hansen, who described a "battalion" of pro-industry scientists that stands ready to criticize independent researchers like Séralini whenever their studies are released.

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Response to defacto7 (Reply #2)

Mon Feb 11, 2013, 07:46 AM

8. For decades, I've read about cures that "disappear", too. All games are rigged. nt

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Response to valerief (Reply #8)

Mon Feb 11, 2013, 10:30 AM

16. did you hear about this one?

http://www.8newsnow.com/story/8911926/lettuce-may-help-millions-diagnosed-with-diabetes

from 2008, bought out by Bayer. where'd that lettuce go in the last five years?

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Response to farminator3000 (Reply #16)

Mon Feb 11, 2013, 12:51 PM

24. Nope, didn't see that, but it doesn't surprise me in the least.

But at least once a month we see another damn WINE IS GOOD FOR YOU article.

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Response to kpete (Original post)

Mon Feb 11, 2013, 01:02 AM

4. And so, Glaxo/SmithKline will buy the rights and make sure we can never get the stuff.

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Response to Ken Burch (Reply #4)

Mon Feb 11, 2013, 01:06 AM

5. Only the 1% will have access to the cures.

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Response to glinda (Reply #5)

Mon Feb 11, 2013, 07:46 AM

9. +1 gazillion

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Response to Ken Burch (Reply #4)

Mon Feb 11, 2013, 10:31 AM

17. see #16

whatever would cause you to make such a statement?

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Response to kpete (Original post)

Mon Feb 11, 2013, 02:37 AM

6. Check out-

Oncolytics Biotech. Nasdaq and TSX. Been at it for 10+ years,numerous studies in US,Canada,Britain,Europe for various types of cancers,uses Reolysin a common type of virus with mild flue-like symptoms with almost no side effects in conjunction with chemo. Phase 1,2 and 3 studies underway. In news last week.

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Response to kpete (Original post)

Mon Feb 11, 2013, 09:01 AM

10. Kick & R n/t

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Response to kpete (Original post)

Mon Feb 11, 2013, 09:19 AM

11. i don't mean to discourage anyone , but there are better ways, completely natural

i just don't think that big pharma wants a cure for cancer any more than they want a an asteroid to crash into their lab.

why aren't they studying cannabis? oh, right, they ignore that it helps 200+ diseases, because they can't patent it.

there was a scientist from U of Florida that was GEing lettuce to cure diabetes- bought out by Bayer 5 years ago, no more diabetes cure...
from 2008-
Dr. Daniell says patients would only have to take the pill for weeks, not months or years. Once their immune system responds, they would essentially no longer have the disease. He also says because this is a plant-based therapy, it would only cost pennies to produce. There were no side effects observed in the mice. Human trials are expected to start in the next year.
http://www.diabetesincontrol.com/component/content/article/5989-

diabetes lettuce= GONE from the news, no stories since 2008

***

The late Dr. Tod Mikuriya, a former national administrator of the U.S. government's marijuana research programs, appeared in a film about the business of marijuana prohibition shortly before his 2007 death called "The Union." (The full movie is available on both Netflix and YouTube.)

"After dealing with about 10,000 patents in the last 15 years, I'd say about 200 different medical conditions respond favorably to cannabis," Mikuriya said.
http://www.ibtimes.com/%E2%80%98medical%E2%80%99-marijuana-10-health-benefits-legitimize-legalization-742456

***

from same topic in GD forum-
http://www.huffingtonpost.com/2012/09/19/marijuana-and-cancer_n_1898208.html

"What we found was that his Cannabidiol could essentially 'turn off' the ID-1," Desprez told HuffPost. The cells stopped spreading and returned to normal.
"We likely would not have found this on our own," he added. "That's why collaboration is so essential to scientific discovery."
Desprez and McAllister first published a paper about the finding in 2007. Since then, their team has found that CBD works both in the lab and in animals. And now, they've found even more good news.
"We started by researching breast cancer," said Desprez. "But now we've found that Cannabidiol works with many kinds of aggressive cancers--brain, prostate--any kind in which these high levels of ID-1 are present."
Desprez hopes that clinical trials will begin immediately.
"We've found no toxicity in the animals we've tested, and Cannabidiol is already used in humans for a variety of other ailments," he said. Indeed, the compound is used to relieve anxiety and nausea, and, since it is non-psychoactive, does not cause the "high" associated with THC.

-skip-

While marijuana advocates will surely praise the discovery, Desprez explained that it's not so easy as just lighting up.
"We used injections in the animal testing and are also testing pills," he said. "But you could never get enough Cannabidiol for it to be effective just from smoking."

Furthermore, the team has started synthesizing the compound in the lab instead of using the plant in an effort to make it more potent.
"It's a common practice," explained Desprez. "But hopefully it will also keep us clear of any obstacles while seeking approval."

...

that part about not enough from smoke- obviously you don't smoke when you have cancer- you EAT the weed, duh.
you can definitely eat enough, esp. if you make hash.
sucks that they have to synthesize it because the laws are so idiotic.

***

now, why would a scientist ignore cannabis and try to GE viruses? oh, right.

After joining Onyx as the first oncology development employee, he created and initiated clinical development plans in partnership with Bayer for Nexavar, now a marketed product for kidney and liver cancers. He also led the development of a first-in-class oncolytic virus therapeutic through to Phase 3, a corporate partnership with Warner-Lambert and an initial public offering during his tenure. He has been a consultant in cancer biotherapeutics for Pfizer, Novartis, BiogenIdec, Schering AG and other leading oncology companies.

Sixteen patients given a high dose of the therapy survived for 14.1 months on average, compared to 6.7 months for the 14 who got the low dose.

plus, it doesn't seem to work that well, compared to a complete cure from natural CBD.

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Response to farminator3000 (Reply #11)

Mon Feb 11, 2013, 10:09 AM

13. mon, bob marley died of cancer.

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Response to mopinko (Reply #13)

Mon Feb 11, 2013, 10:18 AM

14. i found a conspiracy free account of his death, wow, the internet is getting better!

This brings the question, why would Bob Marley get skin cancer on his toe? First we must remember that Bob was diagnosed with an Acral Melanoma. This type accounts for 70 per cent of melanoma in darkly pigmented individual or Asians. It typically occurs on non-sun exposed areas as the palm, the sole and mucosa and under the nails. It is characterised by a dark mole or spot that can turn cancerous.

This can happen by repeated trauma to the area or for no reason at all. Studies have shown that darker skin people are more likely to present with advanced disease stage III -IV than whites who typically appear with stage I. This is exactly what happened in Mr Marley’s case. He presented with a skin cancer stage 3-4 on his toe.

He also was fair-skinned of a white father. Being fair-skinned is a risk factor for skin cancer. Melanoma can take years to spread. Most likely he had a pigmented dark mole under his right great toe nail, the continued playing of soccer traumatized the dark mole, which turned cancerous then into a sore. When his cancer was discovered (summer of 1977) the recommendation to amputate his toe would most certainly have saved his life. The surgical excision done and the skin graft (July 1977) was ineffective or simply too late.
http://repeatingislands.com/2011/04/15/a-death-by-skin-cancer-the-bob-marley-story/

he didn't smoke with his big toe.

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Response to farminator3000 (Reply #14)

Mon Feb 11, 2013, 12:19 PM

21. people don't smoke with their livers, either.

i am well aware of the type of cancer that marley died of. mj is a fine thing, but it ain't a magic cure all. and having medically active components doesn't mean that smoking will keep you from getting sick. it has a component that helps glaucoma, but it is not present in anything like a therapeutic level.

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Response to mopinko (Reply #21)

Mon Feb 11, 2013, 12:40 PM

22. there also aren't by-products of smoke to bother your liver when eaten

um.

Glaucoma increases pressure in the eyeball, which can lead to vision loss. Smoking marijuana reduces pressure in the eyes. Your doctor can prescribe other medications to treat glaucoma, but these can lose their effectiveness over time.
http://www.livescience.com/6232-marijuana-glaucoma.html

check out those most popular articles from that link.

of course MJ is magic, what other thing can help 200+ diseases? ok, maybe garlic.

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Response to mopinko (Reply #13)

Mon Feb 11, 2013, 10:32 AM

18. didja miss this part?

The late Dr. Tod Mikuriya, a former national administrator of the U.S. government's marijuana research programs, appeared in a film about the business of marijuana prohibition shortly before his 2007 death called "The Union." (The full movie is available on both Netflix and YouTube.)

"After dealing with about 10,000 patents in the last 15 years, I'd say about 200 different medical conditions respond favorably to cannabis," Mikuriya said.
http://www.ibtimes.com/%E2%80%98medical%E2%80%99-marijuana-10-health-benefits-legitimize-legalization-742456

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Response to mopinko (Reply #13)

Mon Feb 11, 2013, 11:39 AM

19. plus, they didn't figure it out about MJ till AFTER he died.

check the latest research, MJ is GOOD STUFF...

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Response to kpete (Original post)

Mon Feb 11, 2013, 12:08 PM

20. Someone please reassure me...

... That a chance mutation cannot easily change that headline to "Genetically engineered virus kills EVERYONE."

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Response to sofa king (Reply #20)

Mon Feb 11, 2013, 12:41 PM

23. sorry.

i'm just a farmer.

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Response to kpete (Original post)

Mon Feb 11, 2013, 11:33 PM

25. Uh, they all died 8 months after the patients receiving the low dose..

Just say'in...

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