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muriel_volestrangler

(101,295 posts)
Tue Sep 27, 2016, 01:20 PM Sep 2016

Exclusive: World’s first baby born with new “3 parent” technique

Source: New Scientist

It’s a boy! A five-month-old boy is the first baby to be born using a new technique that incorporates DNA from three people, New Scientist can reveal. “This is great news and a huge deal,” says Dusko Ilic at King’s College London, who wasn’t involved in the work. “It’s revolutionary.”

The controversial technique, which allows parents with rare genetic mutations to have healthy babies, has only been legally approved in the UK. But the birth of the child, whose Jordanian parents were treated by a US-based team in Mexico, should fast-forward progress around the world, say embryologists.

The boy’s mother carries genes for Leigh syndrome, a fatal disorder that affects the developing nervous system. Genes for the disease reside in DNA in the mitochondria, which provide energy for our cells and carry just 37 genes that are passed down to us from our mothers. This is separate from the majority of our DNA, which is housed in each cell’s nucleus.
...
But this technique wasn’t appropriate for the couple – as Muslims, they were opposed to the destruction of two embryos. So Zhang took a different approach, called spindle nuclear transfer. He removed the nucleus from one of the mother’s eggs and inserted it into a donor egg that had had its own nucleus removed. The resulting egg – with nuclear DNA from the mother and mitochondrial DNA from a donor – was then fertilised with the father’s sperm.



Read more: https://www.newscientist.com/article/2107219-exclusive-worlds-first-baby-born-with-new-3-parent-technique/

46 replies = new reply since forum marked as read
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Exclusive: World’s first baby born with new “3 parent” technique (Original Post) muriel_volestrangler Sep 2016 OP
Designer baby are a reality now. NWCorona Sep 2016 #1
Cool. Hopefully there will be a world ... GeorgeGist Sep 2016 #2
And we want this why? LisaM Sep 2016 #3
Prognosis of Leigh disease ck4829 Sep 2016 #6
That's where it starts. NWCorona Sep 2016 #9
'eugenic' in the sense that many babies with the mother's mitochondria will die muriel_volestrangler Sep 2016 #21
It gives a tool to rid unfortunate people from carrying the gene at all. which means the possible shraby Sep 2016 #23
With 3 parents that baby's going to have some inheritance someday bucolic_frolic Sep 2016 #4
They are going to fuck around and have some messed up looking humans in 200 years snooper2 Sep 2016 #5
maybe this is one of the next steps in our evolution Raster Sep 2016 #7
No, because it uses mitochondrial DNA that is very common muriel_volestrangler Sep 2016 #22
There will be a law of unintended consequences result, that's for sure. LisaM Sep 2016 #8
That book is brilliant and so ahead of its time. NWCorona Sep 2016 #11
Yes, it's a great read. LisaM Sep 2016 #13
I'll have to check that out. I really liked Wanderlust and Men Explain Things to Me. NWCorona Sep 2016 #15
I had actually just re-read "Middlemarch" (a perennial favorite of mine) LisaM Sep 2016 #16
I totally get that. NWCorona Sep 2016 #17
We are reading "Men Explain Things to Me" right now for our book club womanofthehills Sep 2016 #34
We will be here soon enough NWCorona Sep 2016 #10
Why does that remind me of this? BumRushDaShow Sep 2016 #19
Q was always fucking with Picard lol NWCorona Sep 2016 #20
The character was great BumRushDaShow Sep 2016 #26
Yup! NWCorona Sep 2016 #27
Are you predicting that the child will be very ill, but live? muriel_volestrangler Sep 2016 #25
At least when the baby's older Liberalagogo Sep 2016 #12
This scares the shit out of me..... Whenever we mess with nature we fuck things up groundloop Sep 2016 #14
Agreed. LisaM Sep 2016 #18
It's stopping a child dying. Have vaccines and antibiotics - "messing with nature" - fucked muriel_volestrangler Sep 2016 #24
Thanks for your comments on this JustAnotherGen Sep 2016 #28
Humanity has been "messing with nature" ever since we discovered how to make fire. Odin2005 Sep 2016 #38
Bullshit. MicaelS Sep 2016 #41
So, this is cool, but a GMO potato causes outrage. nt Dreamer Tatum Sep 2016 #29
Goddamned elitist french fries! randome Sep 2016 #42
Get ready for the master race... Blue_Tires Sep 2016 #30
How do you see functioning mitochondria as part of "the master race"? muriel_volestrangler Sep 2016 #31
Slippery slope.... Blue_Tires Sep 2016 #32
They didn't 'tweak' the mitochondria; they used a functioning set muriel_volestrangler Sep 2016 #33
Tomorrow major tweaks. I say bring it on. randome Sep 2016 #40
Like Ford Prefect and semi-cousin Zaphod Beeblebrox who share three of the same mothers nt Xipe Totec Sep 2016 #35
i see this more comparable to organ transplants than designer babies JI7 Sep 2016 #36
There is NO, repeat NO, genetic modification done here. Thor_MN Sep 2016 #37
Of course this has brought out the terrified Luddites. Odin2005 Sep 2016 #39
But saying we should do it because that's how it's always been done The2ndWheel Sep 2016 #44
Ask questions. MicaelS Sep 2016 #45
Should/Shouldn't type questions The2ndWheel Sep 2016 #46
how do the overly religious justify the several failures needed to create one viable 'male' fetus? Sunlei Sep 2016 #43

ck4829

(35,042 posts)
6. Prognosis of Leigh disease
Tue Sep 27, 2016, 01:35 PM
Sep 2016

"Different genetic causes and types of Leigh syndrome have different prognoses, though all are poor. The most severe forms of the disease, caused by a full deficiency in one of the affected proteins, cause death at a few years of age. If the deficiency is not complete, the prognosis is somewhat better and an affected child is expected to survive 6–7 years, and in rare cases, to their teenage years."

https://en.wikipedia.org/wiki/Leigh_disease#Prognosis

This should be available to all, if that hurdle is crossed, diseases like this could become a thing of the past.

muriel_volestrangler

(101,295 posts)
21. 'eugenic' in the sense that many babies with the mother's mitochondria will die
Tue Sep 27, 2016, 02:41 PM
Sep 2016

and this one won't. Why would you say 'ugh' to that?

Most people have fully functioning mitochondria. And we get it all from our mothers, so it's basically the same in all siblings, and in all the children the daughters have, and so on. So people's mitochondrial DNA is very similar, apart from when there's a copying mistake , and occasionally that produces a syndrome like this. This corrects a small but fatal error in the DNA.

shraby

(21,946 posts)
23. It gives a tool to rid unfortunate people from carrying the gene at all. which means the possible
Tue Sep 27, 2016, 02:44 PM
Sep 2016

eradication of a horrid disease.

muriel_volestrangler

(101,295 posts)
22. No, because it uses mitochondrial DNA that is very common
Tue Sep 27, 2016, 02:43 PM
Sep 2016

The faulty mtDNA tends to kill those with it, while the extremely common, fully functioning type is what survives. This will be the functioning DNA surviving, but without the baby deaths.

LisaM

(27,800 posts)
8. There will be a law of unintended consequences result, that's for sure.
Tue Sep 27, 2016, 01:36 PM
Sep 2016

Coincidentally, I'm just reading "Frankenstein" at the moment, so this is just flat out scary.

LisaM

(27,800 posts)
13. Yes, it's a great read.
Tue Sep 27, 2016, 02:01 PM
Sep 2016

I actually picked it up (I should have read it long ago) because it was referenced very movingly in "The Faraway Nearby" by Rebecca Solnit, another good book.

NWCorona

(8,541 posts)
15. I'll have to check that out. I really liked Wanderlust and Men Explain Things to Me.
Tue Sep 27, 2016, 02:13 PM
Sep 2016

I've passed up a lot of classics back in the day because I thought I couldn't relate.

LisaM

(27,800 posts)
16. I had actually just re-read "Middlemarch" (a perennial favorite of mine)
Tue Sep 27, 2016, 02:18 PM
Sep 2016

and I figured that it would be a good time to pick up another 19th century book, since I was already kind of in the cadence.

womanofthehills

(8,688 posts)
34. We are reading "Men Explain Things to Me" right now for our book club
Tue Sep 27, 2016, 06:19 PM
Sep 2016

Perfect timing. I need to check out her other books.

muriel_volestrangler

(101,295 posts)
25. Are you predicting that the child will be very ill, but live?
Tue Sep 27, 2016, 02:49 PM
Sep 2016

Why do you think the child will be different from others?

muriel_volestrangler

(101,295 posts)
24. It's stopping a child dying. Have vaccines and antibiotics - "messing with nature" - fucked
Tue Sep 27, 2016, 02:47 PM
Sep 2016

things up?

What is your opinion of fertility treatment?

Odin2005

(53,521 posts)
38. Humanity has been "messing with nature" ever since we discovered how to make fire.
Wed Sep 28, 2016, 09:08 AM
Sep 2016

Hunter-Gathers were doing controlled burns to improve the productivity of their territories tens of thousands of years ago.

MicaelS

(8,747 posts)
41. Bullshit.
Wed Sep 28, 2016, 09:22 AM
Sep 2016

Eradicating Smallpox, Polio and other nasty diseases is " messing with nature". Should we have not done that?

Considering how many people suffer from genetic illnesses, don't you think they would love to never have them in the first place?

We have been messing with nature since we first climbed down from the trees.

FFS, some people on the Left are as bad as the RW when it comes to anti-science rhetoric.

 

randome

(34,845 posts)
42. Goddamned elitist french fries!
Wed Sep 28, 2016, 09:31 AM
Sep 2016

Man was not meant to fry the gentle potato!
[hr][font color="blue"][center]Don't ever underestimate the long-term effects of a good night's sleep.[/center][/font][hr]

Blue_Tires

(55,445 posts)
30. Get ready for the master race...
Tue Sep 27, 2016, 04:58 PM
Sep 2016

This is the part where I ask if all this trouble was worth it instead of adoption...

And God help this "perfect" child if he develops some other kind of disease, or if the scientists got their math wrong...

muriel_volestrangler

(101,295 posts)
31. How do you see functioning mitochondria as part of "the master race"?
Tue Sep 27, 2016, 05:08 PM
Sep 2016

The desire of people to have children of their own is strong. Adoption also has complications about pressure on people or cultures to give up children.

muriel_volestrangler

(101,295 posts)
33. They didn't 'tweak' the mitochondria; they used a functioning set
Tue Sep 27, 2016, 05:22 PM
Sep 2016

like the vast majority of us have. There's very little variation in mtDNA, which is why it's an easy way to find out the spread of populations over thousands of years.

 

randome

(34,845 posts)
40. Tomorrow major tweaks. I say bring it on.
Wed Sep 28, 2016, 09:14 AM
Sep 2016

This IS the next step in our evolution, just as building cities and spaceships has been.
[hr][font color="blue"][center]Don't ever underestimate the long-term effects of a good night's sleep.[/center][/font][hr]

 

Thor_MN

(11,843 posts)
37. There is NO, repeat NO, genetic modification done here.
Tue Sep 27, 2016, 08:27 PM
Sep 2016

Genetic material from the father, intact, was combined with genetic material from the mother, intact and placed in an egg from a donor, with it's genetic material removed. The mitochondrial dna, which is completely separate from the chromosomal dna, came from the donor egg. That's where the sensational "three parents" headlines come from. There was NO gene splicing done.

Those that are fearful of this are showing their ignorance of how cells work.

The2ndWheel

(7,947 posts)
44. But saying we should do it because that's how it's always been done
Wed Sep 28, 2016, 09:48 AM
Sep 2016

is doing things because of tradition. Not allowing people to ask questions that you don't approve of, and attempting to shame them with name calling, that's usually frowned upon. It's a little on the fundamentalist side.

MicaelS

(8,747 posts)
45. Ask questions.
Wed Sep 28, 2016, 10:40 AM
Sep 2016

But let them be based in rational thought processes, not just emotion based rhetoric of "Ooh, I'm scared".

The2ndWheel

(7,947 posts)
46. Should/Shouldn't type questions
Wed Sep 28, 2016, 11:24 AM
Sep 2016

They're always going to be from the emotional side rather than they strict fact side. Even the but it saves children, or keeps people alive longer reasons for doing this or that is based on emotion. It's not like we're running low on people.

Sunlei

(22,651 posts)
43. how do the overly religious justify the several failures needed to create one viable 'male' fetus?
Wed Sep 28, 2016, 09:37 AM
Sep 2016

Several eggs enuclicated, parts discarded, several that failed midrange, and then failures when some embryos were not 'normal'. On top of that the parents lost two children and this child may develop the defect anyway.

"used this approach to create five embryos, only one of which developed normally"

"1% of remaining mutated DNA may replicate to higher percentage & cause the disease in future"

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