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Sun Jan 27, 2013, 05:50 PM

Vaccine would give intense hangover after one sip of alcohol

Good idea for those trying to stop drinking?

http://www.newser.com/story/161724/vaccine-will-give-you-hangover-after-just-one-sip.html


(NEWSER) – Imagine having a vicious hangover after just one sip of booze. Alcoholics around the world will face that very nightmare scenario if an experimental vaccine reaches the marketplace, the Daily Mail reports. Scientists at the University of Chile have designed a drug they say will give anyone who consumes alcohol an accelerated heartbeat, intense nausea, and general sickness. The vaccine works by telling the liver not to express genes that metabolize alcohol—but a scientist involved in the study warns it's no cure-all.

"People who end up alcoholic have a social problem, a personality problem because they’re shy, whatever, and then they are depressed, so it’s not so simple," he tells the Santiago Times. But solving the chemical aspect of alcoholism "could help quite a bit." The vaccine is scheduled to undergo a preclinical trial on mice next month before being tested on people in November. It resembles an old drug called Disulfiram, which was so awful that people simply stopped taking it. But the new vaccine would last for 6 solid months upon injection.

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Arrow 16 replies Author Time Post
Reply Vaccine would give intense hangover after one sip of alcohol (Original post)
gollygee Jan 2013 OP
RayTy Jan 2013 #1
bunnies Jan 2013 #2
customerserviceguy Jan 2013 #8
bunnies Jan 2013 #9
gollygee Jan 2013 #10
Coyote_Tan Jan 2013 #11
gollygee Jan 2013 #13
Skip Intro Jan 2013 #16
hobbit709 Jan 2013 #3
randome Jan 2013 #5
Th1onein Jan 2013 #15
Takket Jan 2013 #4
elleng Jan 2013 #6
cbayer Jan 2013 #7
seabeyond Jan 2013 #12
Th1onein Jan 2013 #14

Response to gollygee (Original post)

Sun Jan 27, 2013, 05:55 PM

1. i would say give this to convicted drunk drivers

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Response to gollygee (Original post)

Sun Jan 27, 2013, 05:57 PM

2. Clockwork Orange anyone?

How creepy.

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Response to bunnies (Reply #2)

Sun Jan 27, 2013, 06:36 PM

8. I'm with you there

I can envision this being administered without consent, from a variety of entities, ranging from government to vindictive exes. And it frightens me even to contemplate the so-called "consent" cases.

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Response to customerserviceguy (Reply #8)

Sun Jan 27, 2013, 07:55 PM

9. exactly.

And dont you just love how theyre calling it a "vaccine"?! Hmmm. Mandatory vaccination until the age of 21? That would NEVER happen.

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Response to bunnies (Reply #9)

Sun Jan 27, 2013, 07:57 PM

10. I thought the word "vaccine" was a strange one for this

Isn't a vaccine specifically to protect you from catching some contagious disease?

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Response to gollygee (Reply #10)

Sun Jan 27, 2013, 08:15 PM

11. Hazard of calling alcoholism a disease...

 

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Response to Coyote_Tan (Reply #11)

Sun Jan 27, 2013, 08:28 PM

13. Well it isn't contagious regardless

Aren't vaccines just to give "herd immunity"?

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Response to customerserviceguy (Reply #8)

Sun Jan 27, 2013, 08:51 PM

16. Indeed. If banning of guns can save "just one life..."

Can mandatory vaccines, using the same justification, be far behind?

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Response to gollygee (Original post)

Sun Jan 27, 2013, 05:58 PM

3. Wonder what other side effects it will have?

you know, like the ones they gloss over so fast in the commercials.

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Response to hobbit709 (Reply #3)

Sun Jan 27, 2013, 06:03 PM

5. In concept, I don't have a problem with it, but what else might it do to the liver?

It sounds too good to be true that it would only affect the liver in 'good' ways.

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Response to randome (Reply #5)

Sun Jan 27, 2013, 08:46 PM

15. Alcohol is toxic to the central nervous system--this is WHY we need that enzyme.

This is one of the worst ideas I've seen in a long time.

You'd be much safer increasing glycogen synthesis. I suspect that it is the suppression of glycogen synthesis in alcoholics that causes the cravings for alcohol.

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Response to gollygee (Original post)

Sun Jan 27, 2013, 06:02 PM

4. yikes

"vaccine works by telling the liver not to express genes that metabolize alcohol"

I don't think it is a good idea to mess around with the functioning of the liver. That could have some pretty brutal side effects that make a hangover look like a picnic.

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Response to gollygee (Original post)

Sun Jan 27, 2013, 06:06 PM

6. The guy is wrong, saying

"People who end up alcoholic have a social problem, a personality problem because they’re shy, whatever, and then they are depressed, so it’s not so simple."

People don't 'end up' alcoholic, they/we either are or are not; its a genetic thing. http://www.lakesidemilam.com/UnderTheInfluence.htm

This vaccine might help alcoholics, and heavy drinkers, by providing a stronger incentive to stop drinking than other approaches,

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Response to gollygee (Original post)

Sun Jan 27, 2013, 06:09 PM

7. Six months? That's too long, imo. What's wrong with Antabuse?

It does the same thing but has a much shorter half life.

The problem is that sometimes it may be necessary to be exposed to alcohol. It's in all kinds of products and medical supplies. People on Antabuse (disulfarim) can stop temporarily if the need be. With this product, they will be in jeopardy for 6 months. That's just too long, imo.

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Response to gollygee (Original post)

Sun Jan 27, 2013, 08:17 PM

12. i watched my brother destroy his life for 3 decades. it is the genetic alcholism, that is so

horrible.

his son is walking in his footsteps and he is only 19. we have a clear path he is taking. as we did with my brother, because of seeing moms brother.

my brother couldnt live without his alcohol. i do not believe. but, it is not too late for his son. (his other two kids refuse to drink).

if i could get that boy to do something like this, i would be all for it. anything to help him not walk this destructive path.

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Response to gollygee (Original post)

Sun Jan 27, 2013, 08:39 PM

14. I don't think this is a good idea.

Especially for determined drinkers. The enzyme whose gene they are suppressing is alcohol dehydrogenase, which is necessary for the proper metabolism of alcohol.

Don't get me wrong--I understand that that is the purpose of suppressing the expression of this enzyme, but alcohol dehydrogenase has more than just this function.

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