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Sat Jan 26, 2013, 05:18 PM

 

Girl 'leukemia free' after being treated with HIV

Say what you will, these medical people are magicians, scientists of the highest order.

http://news.ninemsn.com.au/world/2012/12/11/19/11/girl-leukemia-free-after-being-treated-with-hiv

A seven-year-old US girl who was near death with leukemia now shows no sign of the disease after doctors treated her with HIV.

Emma Brooke-Whitehead had undergone extended chemotherapy without success when doctors at Children's Hospital of Philadelphia decided to try the groundbreaking new treatment about eight months ago.

"This treatment was really her only chance," pediatric oncologist Stephen Grupp told ABC News.

The treatment works by using a disabled version of HIV to retrain a patient's disease-fighting white blood cells to kill cancer cells.

Doctors removed millions of white blood cells from Emma, who was diagnosed with acute lymphoblastic leukemia at age five, and inserted the new gene before pumping them back into her body.

27 replies, 2999 views

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Arrow 27 replies Author Time Post
Reply Girl 'leukemia free' after being treated with HIV (Original post)
2on2u Jan 2013 OP
NYC_SKP Jan 2013 #1
Robb Jan 2013 #2
PeaceNikki Jan 2013 #3
alcibiades_mystery Jan 2013 #4
jberryhill Jan 2013 #5
DirkGently Jan 2013 #6
99Forever Jan 2013 #7
UnrepentantLiberal Jan 2013 #8
2on2u Jan 2013 #9
bunnies Jan 2013 #12
UnrepentantLiberal Jan 2013 #13
bunnies Jan 2013 #14
kwijybo Jan 2013 #10
bunnies Jan 2013 #11
sakabatou Jan 2013 #15
FLyellowdog Jan 2013 #16
dlwickham Jan 2013 #17
2on2u Jan 2013 #19
dlwickham Jan 2013 #23
Drunken Irishman Jan 2013 #18
DeschutesRiver Jan 2013 #20
DeschutesRiver Jan 2013 #22
Recursion Jan 2013 #24
DeschutesRiver Jan 2013 #25
frustrated_lefty Jan 2013 #21
backscatter712 Jan 2013 #26
rjj621 Jan 2013 #27

Response to 2on2u (Original post)

Sat Jan 26, 2013, 05:20 PM

1. wow. nt

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Response to 2on2u (Original post)

Sat Jan 26, 2013, 05:21 PM

2. Holy crap.

Remarkable. Suddenly leeches seem tame.

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Response to 2on2u (Original post)

Sat Jan 26, 2013, 05:26 PM

3. Isn't this story amazing?!?!? Take a look at the video here:

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Response to 2on2u (Original post)

Sat Jan 26, 2013, 05:29 PM

4. HIV and Leukemia act in opposite ways, yes?

Where leukemia overproduces immune cells, while HIV is cytotoxic?

Super interesting.

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Response to 2on2u (Original post)

Sat Jan 26, 2013, 05:37 PM

5. O M G

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Response to 2on2u (Original post)

Sat Jan 26, 2013, 05:44 PM

6. Whoa. nt

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Response to 2on2u (Original post)

Sat Jan 26, 2013, 05:46 PM

7. Intriguing.

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Response to 2on2u (Original post)

Sat Jan 26, 2013, 05:54 PM

8. I thought this was going to be woo.

 

This is unreal. Using one horrible disease to fight another. Amazing.

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Response to UnrepentantLiberal (Reply #8)

Sat Jan 26, 2013, 05:57 PM

9. Why not just learn to see the truth.... there is no woo.

 

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Response to UnrepentantLiberal (Reply #8)

Sat Jan 26, 2013, 06:07 PM

12. woo?

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Response to bunnies (Reply #12)

Sat Jan 26, 2013, 06:14 PM

13. This:

 

http://rationalwiki.org/wiki/Woo

(I don't think this story is woo.)

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Response to UnrepentantLiberal (Reply #13)

Sat Jan 26, 2013, 06:16 PM

14. Thank you!

I knew I was missing something.

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Response to 2on2u (Original post)

Sat Jan 26, 2013, 06:04 PM

10. Sometimes

It takes a monster to kill a monster... Right now, it's a tightly focused solution-- I wonder how long it will be before they get it to be a little more general.

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Response to 2on2u (Original post)

Sat Jan 26, 2013, 06:06 PM

11. Thats fucking AWESOME.

In the real sense of the word. wow.

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Response to 2on2u (Original post)

Sat Jan 26, 2013, 06:33 PM

15. Wow...

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Response to 2on2u (Original post)

Sat Jan 26, 2013, 07:20 PM

16. We are getting closer and closer to stopping this scurge.

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Response to 2on2u (Original post)

Sat Jan 26, 2013, 07:39 PM

17. interesting

I'm sure there's more to this than what the article states

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Response to dlwickham (Reply #17)

Sat Jan 26, 2013, 07:42 PM

19. Love your sig line btw. n/t

 

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Response to 2on2u (Reply #19)

Sun Jan 27, 2013, 01:37 PM

23. thank you

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Response to 2on2u (Original post)

Sat Jan 26, 2013, 07:41 PM

18. My brother died of leukemia at the age of 12...

He was diagnosed only two or so weeks before he died. It was devastating for my mom. She always told me if they could find a cure for HIV, they'd find a cure for leukemia.

Well I guess they treated it with HIV instead. Crazy!

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Response to 2on2u (Original post)

Sat Jan 26, 2013, 09:28 PM

20. This is amazing.

Am glad you posted it, because I haven't seen this on the news yet (might have missed it there).

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Response to DeschutesRiver (Reply #20)

Sat Jan 26, 2013, 10:56 PM

22. "New twist in Redmond girl's fight with leukemia" - a local child is going to try this treatment

After I read this thread, I remembered an article I
So I went back to read the article, and they had updated it with the news that she will now be trying this new disabled HIV treatment. What a small world that this news has touched us here in Central Oregon as well.

I hope it works for Avrey, and will be following her story with renewed hope.

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Response to DeschutesRiver (Reply #20)

Sun Jan 27, 2013, 01:39 PM

24. This broke last year sometime with the preliminary results

They're only releasing the full data now. What a fascinating modern age we live in!

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Response to Recursion (Reply #24)

Wed Jan 30, 2013, 01:27 PM

25. Yes, we are lucky to be here in this age where we get to witness the start of such progress! nt

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Response to 2on2u (Original post)

Sat Jan 26, 2013, 09:49 PM

21. Gene therapy.

They're using HIV as a vector for delivering a therapeutic gene.

Similar vectors have been used previously to attempt cures (of ADA most notably). The irony is, these types of vectors can't currently be used for treating most diseases because the therapeutic gene randomly integrates in the chromosome. As a consequence of this random integration, there's a risk of them causing cancer, and several patients in previous clinical trials ended up developing....wait for it....leukemia.

Consequently, cancer is one of the few diseases which can be readily targeted using the technology: the patient already has cancer, so the risk isn't (as much of) an issue. It's good to see the field advancing. A lot of effort went into making gene therapy a viable option over the last 20 years.

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Response to frustrated_lefty (Reply #21)

Wed Jan 30, 2013, 01:32 PM

26. That's basically it.

The HIV used in this case was disabled, so it doesn't have its normally lethal and sickening effects, and instead was turned into a vehicle for delivering DNA to white blood cells to enable them to recognize cancer cells as hostile, and thus target them.

I'm glad it worked in this case.

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Response to 2on2u (Original post)

Wed Jan 30, 2013, 01:44 PM

27. Such a great story

I remember hearing something about it when I was coming into work one day and meant to look it up when I got here but like most things I hear or think about while driving and want to look up... I forgot. Thanks for posting this, I thought the idea of using disabled HIV was fascinating and curious to see what other forms of cancer we will eventually be able to use it against.

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