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Tue Dec 4, 2012, 07:33 AM

 

Contemptuous Merck emails show corp knew Fosamax linked to jawbone necrosis

As early as 2004, Merck knew its blockbuster osteoporosis drug Fosamax was causing osteonecrosis of the jaw (ONJ) after in-office dental procedures and ridiculed afflicted patients. The condition, also called jawbone death, occurs when traumatized tissue doesn't heal but becomes "necrotic" and dies. "Ma toot hurts so bad" mimicked Merck bone scientist Don Kimmel in a 2004 email to Merck health science consultant Sharon Scurato about the type of patient who was developing ONJ. Such a patient "could be an oral hog," wrote Kimmel, then a bone scientist in Merck's department of Molecular Endocrinology/Bone Biology and trained as a dentist--someone with pre-existing infections and periodontal disease who omits preventative care.

Newly available emails and internal Merck documents reveal the company was far from concerned or surprised when ONJ-links to Fosamax surfaced in the early 2000's and launched elaborate spin campaigns to keep the $3 billion a year pill afloat. In fact, animal studies revealed ONJ in rats given bisphosphonates (the class of drugs Fosamax belongs to) as early as 1977 Kimmel admitted under oath in 2008.

Thousands of lawsuits have been filed on behalf of patients who say they developed ONJ after dental procedures like tooth extraction because they took Fosamax. Treating ONJ is almost impossible said dentists and oral surgeons quoted the Review-Journal in 2005, because "further surgery in an effort to correct the problem only exacerbates it, leaving the patient with even more exposed bone and even more disfigured," Jaw removal, bone grafts, and even tracheostomies were reported by the News-Press in 2006. "Even short-term oral use of alendronate led to ONJ in a subset of patients after certain dental procedures were performed, read a study in the Journal of the American Dental Association in 2009.

Besides attributing ONJ to patients' bad oral hygiene and, tautologically, their advanced years, Merck withheld crucial safety data from the American Society for Bone and Mineral Research (ASBMR) when the group sought to develop a position paper on bisphosphonate-related ONJ...

http://www.alternet.org/speakeasy/martharosenberg/contemptuous-internal-merck-emails-revealed

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Reply Contemptuous Merck emails show corp knew Fosamax linked to jawbone necrosis (Original post)
HiPointDem Dec 2012 OP
leftyohiolib Dec 2012 #1
PETRUS Dec 2012 #2
Cal Carpenter Dec 2012 #3
WinkyDink Dec 2012 #4
Poll_Blind Dec 2012 #5
antigop Dec 2012 #6

Response to HiPointDem (Original post)

Tue Dec 4, 2012, 07:38 AM

1. they'll fire a couple of sevice reps and call the whole thing solved pay a 50 dollar fine

 

sweep everything under the rug and roll on unphazed

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Response to HiPointDem (Original post)

Tue Dec 4, 2012, 10:40 AM

2. K&R

There are giant flaws in the patent system.

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Response to HiPointDem (Original post)

Tue Dec 4, 2012, 10:57 AM

3. Disgusting

Nothing is done in the public interest, not even medicine.

It is done in the pursuit of profits.

Be sure this type of behavior is more like a norm than an exception.

Even public essentials are increasingly privatized. It is going in one direction only. THIS is the cliff we should be worried about. Many millions have already fallen off.

Our entire economic system is a big fucking FAIL**. Within and beyond our borders.

**Unless you are in the 1%/ruling class...

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Response to HiPointDem (Original post)

Tue Dec 4, 2012, 11:01 AM

4. Conspiracies don't exist, just remember that. "Too many people" would be involved.

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Response to WinkyDink (Reply #4)

Tue Dec 4, 2012, 11:28 AM

5. Word. nt

PB

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