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Sat Nov 17, 2012, 06:02 PM

Cannabis May Slow Brain Aging

http://healthland.time.com/2012/10/29/how-cannabinoids-may-slow-brain-aging/?iid=obinsite

The over 65 voting bloc may be the least likely to support marijuana legalization, but they might find it's in their best interests to do so. Cannabis' ability to help with inflammation and pain is well known.

In addition, not withstanding the stoner memory-loss stereotype, marijuana may help with Alzheimers, brain aging and degenerative diseases. Cases of Alzheimer's disease are expected to triple over the next 50 years.

Since the mid 2000′s researchers have been building an appreciation for the power of marijuana-like substances that make up the brain’s cannabinoid systems. In animal experiments, for example, synthetic compounds similar to THC—marijuana’s main psychoactive component—have shown promise in preserving brain functions. A 2008 study even demonstrated that a THC-like substance reduced brain inflammation and improved memory in older rats.

Activation of cannabinoid receptors can also reduce brain inflammation in several different ways, which may in turn suppress some of the disease processes responsible for degenerative brain diseases such as Alzheimer’s.

Andras Bilkei-Gorzo of the Institute of Molecular Psychiatry at the University of Bonn in Germany and an author of the study, is encouraged by the expanding knowledge of the brain’s cannabinoid system and its potential for leading to new understanding of aging in the brain. “annabinoid system activity is neuroprotective,” he wrote, and increasing it “could be a promising strategy for slowing down the progression of brain aging and for alleviating the symptoms of neurodegenerative disorders.”

Other studies covered in the review showed that mice bred to lack the cannabinoid receptors have better memories early in life but have more rapid cognitive decline as they age, including inflammation in the hippocampus, a key region for memory. “This finding suggests that, at some point during aging, cannabinoid activity helps maintain normal cognitive functions in mice,” says Daniele Piomelli, professor of neurobiology, anatomy and biological chemistry at the University of California – Irvine, who was not associated with the study.


In 2006, one study showed -

https://www.ncbi.nlm.nih.gov/pubmed/17140265

A molecular link between the active component of marijuana and Alzheimer's disease pathology.

Eubanks LM, Rogers CJ, Beuscher AE 4th, Koob GF, Olson AJ, Dickerson TJ, Janda KD.
Source
Department of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

(The researchers) demonstrate that the active component of marijuana, Delta9-tetrahydrocannabinol (THC), competitively inhibits the enzyme acetylcholinesterase (AChE) as well as prevents AChE-induced amyloid beta-peptide (Abeta) aggregation, the key pathological marker of Alzheimer's disease. Computational modeling of the THC-AChE interaction revealed that THC binds in the peripheral anionic site of AChE, the critical region involved in amyloidgenesis. Compared to currently approved drugs prescribed for the treatment of Alzheimer's disease, THC is a considerably superior inhibitor of Abeta aggregation, and this study provides a previously unrecognized molecular mechanism through which cannabinoid molecules may directly impact the progression of this debilitating disease.

These are things the elderly need to know about in order to make informed decisions. Their health may be improved by such actions.

24 replies, 2167 views

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Arrow 24 replies Author Time Post
Reply Cannabis May Slow Brain Aging (Original post)
RainDog Nov 2012 OP
SubgeniusHasSlack Nov 2012 #1
Cirque du So-What Nov 2012 #2
pipoman Nov 2012 #5
Fumesucker Nov 2012 #10
shanti Nov 2012 #18
Ernesto Nov 2012 #3
felix_numinous Nov 2012 #4
customerserviceguy Nov 2012 #6
RainDog Nov 2012 #8
Enrique Nov 2012 #11
greytdemocrat Nov 2012 #7
RainDog Nov 2012 #9
Blue_In_AK Nov 2012 #12
salinen Nov 2012 #13
Blue_In_AK Nov 2012 #14
benld74 Nov 2012 #15
RebelOne Nov 2012 #16
RainDog Nov 2012 #17
duhneece Nov 2012 #19
Zorra Nov 2012 #20
ErikJ Nov 2012 #21
RainDog Nov 2012 #22
Avalux Nov 2012 #23
cherokeeprogressive Nov 2012 #24

Response to RainDog (Original post)

Sat Nov 17, 2012, 06:06 PM

1. It is the Healing of the Nations.

 

Revelations 22:2

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Response to RainDog (Original post)

Sat Nov 17, 2012, 06:07 PM

2. Retirement can't come soon enough for me

and I hope MJ is legalized or at least decriminalized where I live. Of all life's pleasures that I've denied myself, I miss MJ the most - and that is only due to random drug testing that is part & parcel of working America.

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Response to Cirque du So-What (Reply #2)

Sat Nov 17, 2012, 06:23 PM

5. Legalization should raise the

allowable amount of THC in one's blood from none to allow for use when not working. It would be pretty easy to make those drug test kits show negative unless the blood concentration is higher than say 2.0 ng/ml. It will be interesting to see how the private job sector handles legalization.

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Response to pipoman (Reply #5)

Sat Nov 17, 2012, 06:50 PM

10. The private sector won't change their standards

It's not about the drug per se, it's all about whether you knuckle under to the regime or not.

This whole drug testing thing has become entirely too much a part of our culture to go away in any reasonable length of time.

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Response to Fumesucker (Reply #10)

Sat Nov 17, 2012, 09:07 PM

18. right, and they wouldn't tell you that they

stopped testing, even if they did. let's not forget the money that is involved in testing too...follow the money.

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Response to RainDog (Original post)

Sat Nov 17, 2012, 06:20 PM

3. Works for me.......... NT

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Response to RainDog (Original post)

Sat Nov 17, 2012, 06:23 PM

4. K&R

Great news for people like me with Alzheimer's in the family. Bookmarked for later reading

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Response to RainDog (Original post)

Sat Nov 17, 2012, 06:41 PM

6. Maybe it just seems slower. n/t

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Response to customerserviceguy (Reply #6)

Sat Nov 17, 2012, 06:48 PM

8. LOL



I discovered this woman via this video -

http://topdocumentaryfilms.com/stoned-in-suburbia/

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Response to customerserviceguy (Reply #6)

Sat Nov 17, 2012, 06:50 PM

11. lol

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Response to RainDog (Original post)

Sat Nov 17, 2012, 06:46 PM

7. I need a Twinkie...n/t

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Response to greytdemocrat (Reply #7)

Sat Nov 17, 2012, 06:49 PM

9. Now THAT stuff WILL kill you! :) n/t

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Response to RainDog (Original post)

Sat Nov 17, 2012, 07:07 PM

12. I'm 66, been smoking it pretty regularly since 1967

and feel like I'm about 30. I think there's something to this.

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Response to Blue_In_AK (Reply #12)

Sat Nov 17, 2012, 07:32 PM

13. I know a few

 

like you who wake and bake since the sixties. I think you have good genetics. Most that I know have memory loss and are grandiose.

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Response to salinen (Reply #13)

Sat Nov 17, 2012, 07:35 PM

14. Well, I don't smoke all day, of course,

anymore.

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Response to RainDog (Original post)

Sat Nov 17, 2012, 08:13 PM

15. The wife always says she is the only adult in the house,,,,,

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Response to RainDog (Original post)

Sat Nov 17, 2012, 08:33 PM

16. Can it slow the physical aging process?

If so, I just might take up smoking it again. I have not smoked it for more than 40 years.

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Response to RebelOne (Reply #16)

Sat Nov 17, 2012, 09:03 PM

17. Not that I know of...

but the benefits related to chemo, nausea, epilepsy, MS, alzheimers, glaucoma, depression and anxiety might help add to elderly Americans' quality of life.

Some people have tried using cannabis oil to treat cancers, not just mitigate side-effects of treatment for cancer.

The interesting thing about cannabis and cancer treatment studies from a phase II clinical trial for brain cancer is that the cannabis surrounds the cancer cell and deprives it of the ability to reproduce, while healthy cells are left intact. But that's not from smoking - that's from concentrated oils.

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Response to RainDog (Original post)

Sat Nov 17, 2012, 09:23 PM

19. More reasons to move toward regulation & taxation

Can't wait.

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Response to RainDog (Original post)

Sat Nov 17, 2012, 09:29 PM

20. In that case, I reckon there was about 15 yrs there where my brain

was possibly growing younger each year, if quantity ingested per year is a relative factor.

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Response to RainDog (Original post)

Sat Nov 17, 2012, 09:34 PM

21. Study: Nicotine patch improves brain power

Study: Nicotine patch improves brain power
TRACY CONNOR
Monday, January 09, 2012
A nicotine patch boosted brain power in patients experiencing mild memory and attention problems — a finding that could hold promise for Alzheimer’s research.

The study that produced the discovery looked at men and women with mild cognitive impairment, a condition that does not interfere with daily living but often progresses to dementia.

Half the 74 subjects — all nonsmokers — wore a nicotine. patch for six months, while the others were given a placebo.

The group that got the nicotine did better on cognition tests, although they and their doctors may not have noticed much improvement.

http://articles.nydailynews.com/2012-01-09/news/30609552_1_nicotine-patch-mild-cognitive-impairment-study




Nicotine Could Play Role in Alzheimer's Disease Therapy, Neuroscientists Discover
ScienceDaily (Oct. 13, 2010)

— A team of neuroscientists has discovered important new information in the search for an effective treatment for Alzheimer's disease, the debilitating neurological disorder that afflicts more than 5.3 million Americans and is the sixth-leading cause of death in the United States. Hey-Kyoung Lee, associate professor in the University of Maryland Department of Biology, and her research team have shown that they may be able to eliminate debilitating side effects caused by a promising Alzheimer's drug by stimulating the brain's nicotine receptors.

"By stimulating the Alpha7 receptor with nicotine, we were able to recover normal brain function," explains Lee. "We are very hopeful that this will be a way to overcome the deficits seen with the BACE-1 knockouts."

http://www.sciencedaily.com/releases/2010/10/101013095331.htm

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Response to ErikJ (Reply #21)

Sat Nov 17, 2012, 10:51 PM

22. interesting

something that has been looked at in recreational terms only... tho tobacco is also a sacrament in some traditions.

The second study, however, was using nicotine to counteract a side effect of the standard alzheimer drug, and the study in my OP indicates cannabis has better results than that drug.

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Response to RainDog (Original post)

Sat Nov 17, 2012, 10:53 PM

23. Well imagine that! It may cause short term memory loss....

but it may keep you from losing who you are. Amazing.

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Response to RainDog (Original post)

Sat Nov 17, 2012, 10:55 PM

24. I'm 51 and it makes me think about things I thought about when I was 21. Agree. n/t

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